DegronMD

Uniprot ID: Q16849

Source protein: Receptor-type tyrosine-protein phosphatase-like N

Source gene: PTPRN

Class: DEG_ODPH_VHL_1

Location: 129:142

E3 ligase: VHL

DEGRON score: 0.8447

ASA_SCORE: 76.2429

COIL: 0.7835

CONS_SCORE: 0.3251

DSS_SCORE: 0.7508

HELIX: 0.1766

FCONS_SCORE: 1.0042

RIG_SCORE: 0.5964

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L142S	TCGA-2Y-A9GT	LIHC	TCGA	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.7667
p.L142S	DO219506	LIHC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.7667
p.A130T	TCGA-B5-A0JZ	UCEC	TCGA	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.7139
p.A130T	DO42761	UCEC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.7139
p.S127F	TCGA-EO-A22U	UCEC	TCGA	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.2778
p.S127F	DO43755	UCEC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.2778
p.A150T	TCGA-UE-A6QU	SARC	TCGA	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.1111
p.A150T	DO220285	SARC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.1111
p.R126M	TCGA-VQ-A91D	STAD	TCGA	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.25
p.R126M	DO51783	STAD	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.25
p.G135C	DO52393	LIHM	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.6489
p.K132Q	DO52393	LIHM	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.5833
p.A150P	DO23108	LINC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.1111
p.A150P	DO45041	LINC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.1111
p.Q143H	SIDM00373	Endometrial Carcinoma	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.3056
p.Q143H	ACH-000974	Endometrial/Uterine Cancer	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.3056
p.Q143H	ACH-002026	Endometrial/Uterine Cancer	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.3056
p.Q143H	SNG-M	endometrium	COSMIC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.3056
p.R122H	SIDM00845	Burkitt's Lymphoma	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.1389
p.R122H	SIDM01206	Neuroblastoma	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.1389
p.R122H	ACH-000310	Neuroblastoma	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.1389
p.R122H	ACH-002248	Neuroblastoma	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.1389
p.R122H	IMR-5	autonomic_ganglia	COSMIC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.1389
p.K132R	SIDM00198	Ewing's Sarcoma	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.6126
p.S127Y	SIDM01470	Acute Myeloid Leukemia	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.2778
p.S127Y	ACH-000387	Leukemia	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.2778
p.R133I	SIDM01588	Endometrial Carcinoma	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.6991
p.R133I	ACH-000993	Endometrial/Uterine Cancer	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.6991
p.G148A	ACH-000886	Lung Cancer	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.1667
p.G148A	NCI-H2009	lung	COSMIC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.1667
p.R127H	CCF-STTG1	central_nervous_system	COSMIC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.2778
p.P151L	LU-165	lung	COSMIC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPKRPGPAGELLL

Degron related mutations and impact score

Drug responses associated with PTPRN mutations

All proteins holding degron of LAPKRPGPAGELLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16849	Receptor-type tyrosine-protein phosphatase-like N	DEG_ODPH_VHL_1	129:142	LAPKRPGPAGELLL	VHL	0.8447	More...