DegronMD - Q16875(PFKFB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P464L	TCGA-44-2657	LUAD	TCGA	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation altering degron motif	0.7582
p.P464L	TCGA-NC-A5HT	LUSC	TCGA	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation altering degron motif	0.7582
p.R475G	TCGA-63-A5MU	LUSC	TCGA	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation rewiring degron network	0.1111
p.N460Y	TCGA-86-8585	LUAD	TCGA	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation rewiring degron network	0.2778
p.E469K	TCGA-AP-A0LM	UCEC	TCGA	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation rewiring degron network	0.2778
p.S461C	TCGA-CZ-4863	KIRC	TCGA	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation blocking phosphorylation signal	0.75
p.A468T	DO5521	BRCA	ICGC	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation rewiring degron network	0.3056
p.A469T	DO10244	COAD	ICGC	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation rewiring degron network	0.2778
p.A469T	DO43891	UCEC	ICGC	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation rewiring degron network	0.2778
p.R455G	DO219165	LUSC	ICGC	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation rewiring degron network	0.1389
p.S472N	DO41999	UCEC	ICGC	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation substituting flanking lysine	0.3056
p.R475H	SIDM00933	Breast Carcinoma	GDSC	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation rewiring degron network	0.1111
p.R475H	ACH-000856	Breast Cancer	CCLE	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation rewiring degron network	0.1111
p.R475H	CAL-51	breast	COSMIC	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation rewiring degron network	0.1111
p.S467N	SIDM00789	Colorectal Carcinoma	GDSC	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation altering degron motif	0.818
p.S467N	ACH-000997	Colon/Colorectal Cancer	CCLE	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation altering degron motif	0.818
p.S467N	HCT-15	large intestine	COSMIC	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation altering degron motif	0.818
p.R455H	CAL-51	breast	COSMIC	VTPLAS	DEG_SCF_FBW7_1	462:467	Mutation rewiring degron network	0.1389

Kaplan plot for PFKFB3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PFKFB3

UniProt ID: Q16875

Entrez ID: 5209

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PFKFB3 in