DegronMD

Uniprot ID: Q16875

Source protein: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

Source gene: PFKFB3

Class: DEG_SCF_FBW7_1

Location: 462:467

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 75.2

COIL: 0.9482

CONS_SCORE: 0.227

DSS_SCORE: 0.6727

HELIX: 0.0153

FCONS_SCORE: 1.0207

RIG_SCORE: 0.6396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P464L	TCGA-44-2657	LUAD	TCGA	VTPLAS	DEG_SCF_FBW7_1	0.7582
p.P464L	TCGA-NC-A5HT	LUSC	TCGA	VTPLAS	DEG_SCF_FBW7_1	0.7582
p.R475G	TCGA-63-A5MU	LUSC	TCGA	VTPLAS	DEG_SCF_FBW7_1	0.1111
p.N460Y	TCGA-86-8585	LUAD	TCGA	VTPLAS	DEG_SCF_FBW7_1	0.2778
p.E469K	TCGA-AP-A0LM	UCEC	TCGA	VTPLAS	DEG_SCF_FBW7_1	0.2778
p.S461C	TCGA-CZ-4863	KIRC	TCGA	VTPLAS	DEG_SCF_FBW7_1	0.75
p.A468T	DO5521	BRCA	ICGC	VTPLAS	DEG_SCF_FBW7_1	0.3056
p.A469T	DO10244	COAD	ICGC	VTPLAS	DEG_SCF_FBW7_1	0.2778
p.A469T	DO43891	UCEC	ICGC	VTPLAS	DEG_SCF_FBW7_1	0.2778
p.R455G	DO219165	LUSC	ICGC	VTPLAS	DEG_SCF_FBW7_1	0.1389
p.S472N	DO41999	UCEC	ICGC	VTPLAS	DEG_SCF_FBW7_1	0.3056
p.R475H	SIDM00933	Breast Carcinoma	GDSC	VTPLAS	DEG_SCF_FBW7_1	0.1111
p.R475H	ACH-000856	Breast Cancer	CCLE	VTPLAS	DEG_SCF_FBW7_1	0.1111
p.R475H	CAL-51	breast	COSMIC	VTPLAS	DEG_SCF_FBW7_1	0.1111
p.S467N	SIDM00789	Colorectal Carcinoma	GDSC	VTPLAS	DEG_SCF_FBW7_1	0.818
p.S467N	ACH-000997	Colon/Colorectal Cancer	CCLE	VTPLAS	DEG_SCF_FBW7_1	0.818
p.S467N	HCT-15	large_intestine	COSMIC	VTPLAS	DEG_SCF_FBW7_1	0.818
p.R455H	CAL-51	breast	COSMIC	VTPLAS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16875	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	DEG_SCF_FBW7_1	462:467	VTPLAS	FBXW7	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons