DegronMD - Q16878(CDO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S196L	TCGA-A5-A0G2	UCEC	TCGA	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation rewiring degron network	0.25
p.S196L	DO41235	UCEC	ICGC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation rewiring degron network	0.25
p.S196L	SIDM00118	Colorectal Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation rewiring degron network	0.25
p.S196L	ACH-001081	Colon/Colorectal Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation rewiring degron network	0.25
p.S196L	HCC2998	large intestine	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation rewiring degron network	0.25
p.R188I	TCGA-AJ-A3EL	UCEC	TCGA	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation altering degron motif	0.6991
p.R188I	DO41542	UCEC	ICGC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation altering degron motif	0.6991
p.S194L	TCGA-EY-A1GI	UCEC	TCGA	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation blocking phosphorylation signal	0.75
p.S194L	TCGA-F5-6814	READ	TCGA	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation blocking phosphorylation signal	0.75
p.S194L	DO36556	READ	ICGC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation blocking phosphorylation signal	0.75
p.S194L	DO41211	UCEC	ICGC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation blocking phosphorylation signal	0.75
p.S194L	SIDM00839	Colorectal Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation blocking phosphorylation signal	0.75
p.S194L	ACH-000950	Colon/Colorectal Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation blocking phosphorylation signal	0.75
p.S194L	LoVo	large intestine	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation blocking phosphorylation signal	0.75
p.S196A	DO1094	BRCA	ICGC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation rewiring degron network	0.25
p.G195R	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation rewiring degron network	0.2778
p.G195R	ACH-000766	Lung Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation rewiring degron network	0.2778
p.G195R	NCI-H1648	lung	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation rewiring degron network	0.2778
p.T193A	SIDM00965	Small Cell Lung Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation altering degron motif	0.825
p.T193A	ACH-000800	Lung Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation altering degron motif	0.825
p.T193A	NCI-H446	lung	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation altering degron motif	0.825
p.P190T	SIDM00498	Colorectal Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation altering degron motif	0.7031
p.P190T	ACH-000970	Colon/Colorectal Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation altering degron motif	0.7031
p.P190T	SNU-C5	large intestine	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation altering degron motif	0.7031
p.I187M	SIDM00485	Oral Cavity Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation altering degron motif	0.6507
p.I187M	ACH-000794	Head and Neck Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation altering degron motif	0.6507
p.I187M	BICR22	upper aerodigestive tract	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	187:193	Mutation altering degron motif	0.6507

Kaplan plot for CDO1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDO1

UniProt ID: Q16878

Entrez ID: 1036

Protein name: Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDO1 in