DegronMD

Uniprot ID: Q16878

Source protein: Cysteine dioxygenase type 1

Source gene: CDO1

Class: DEG_SCF_FBW7_1

Location: 187:193

E3 ligase: FBXW7

DEGRON score: 0.9264

ASA_SCORE: 83.1571

COIL: 0.5666

CONS_SCORE: 0.3515

DSS_SCORE: 0.5326

HELIX: 0.0163

FCONS_SCORE: 0.8779

RIG_SCORE: 0.6948

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S196L	TCGA-A5-A0G2	UCEC	TCGA	IRTPNAT	DEG_SCF_FBW7_1	0.25
p.S196L	DO41235	UCEC	ICGC	IRTPNAT	DEG_SCF_FBW7_1	0.25
p.S196L	SIDM00118	Colorectal Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	0.25
p.S196L	ACH-001081	Colon/Colorectal Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	0.25
p.S196L	HCC2998	large_intestine	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	0.25
p.R188I	TCGA-AJ-A3EL	UCEC	TCGA	IRTPNAT	DEG_SCF_FBW7_1	0.6991
p.R188I	DO41542	UCEC	ICGC	IRTPNAT	DEG_SCF_FBW7_1	0.6991
p.S194L	TCGA-EY-A1GI	UCEC	TCGA	IRTPNAT	DEG_SCF_FBW7_1	0.75
p.S194L	TCGA-F5-6814	READ	TCGA	IRTPNAT	DEG_SCF_FBW7_1	0.75
p.S194L	DO36556	READ	ICGC	IRTPNAT	DEG_SCF_FBW7_1	0.75
p.S194L	DO41211	UCEC	ICGC	IRTPNAT	DEG_SCF_FBW7_1	0.75
p.S194L	SIDM00839	Colorectal Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	0.75
p.S194L	ACH-000950	Colon/Colorectal Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	0.75
p.S194L	LoVo	large_intestine	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	0.75
p.S196A	DO1094	BRCA	ICGC	IRTPNAT	DEG_SCF_FBW7_1	0.25
p.G195R	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	0.2778
p.G195R	ACH-000766	Lung Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	0.2778
p.G195R	NCI-H1648	lung	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	0.2778
p.T193A	SIDM00965	Small Cell Lung Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	0.825
p.T193A	ACH-000800	Lung Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	0.825
p.T193A	NCI-H446	lung	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	0.825
p.P190T	SIDM00498	Colorectal Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	0.7031
p.P190T	ACH-000970	Colon/Colorectal Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	0.7031
p.P190T	SNU-C5	large_intestine	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	0.7031
p.I187M	SIDM00485	Oral Cavity Carcinoma	GDSC	IRTPNAT	DEG_SCF_FBW7_1	0.6507
p.I187M	ACH-000794	Head and Neck Cancer	CCLE	IRTPNAT	DEG_SCF_FBW7_1	0.6507
p.I187M	BICR22	upper_aerodigestive_tract	COSMIC	IRTPNAT	DEG_SCF_FBW7_1	0.6507

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRTPNAT

Degron related mutations and impact score

Drug responses associated with CDO1 mutations

All proteins holding degron of IRTPNAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16878	Cysteine dioxygenase type 1	DEG_SCF_FBW7_1	187:193	IRTPNAT	FBXW7	0.9264	More...