DegronMD - Q17RD7(SYT16)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G343W	TCGA-55-8506	LUAD	TCGA	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation altering degron motif	0.7825
p.G343W	DO45390	LUAD	ICGC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation altering degron motif	0.7825
p.G343W	ACH-001096	Sarcoma	CCLE	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation altering degron motif	0.7825
p.E332K	TCGA-D9-A6EC	SKCM	TCGA	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation rewiring degron network	0.2778
p.D334G	TCGA-DD-A4NB	LIHC	TCGA	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation altering degron motif	0.7198
p.S326F	TCGA-HR-A2OG	SKCM	TCGA	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation rewiring degron network	0.1111
p.S326F	DO37511	SKCM	ICGC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation rewiring degron network	0.1111
p.E331G	TCGA-S9-A7QW	LGG	TCGA	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation rewiring degron network	0.25
p.E331G	DO50212	LGG	ICGC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation rewiring degron network	0.25
p.G343R	DO225009	BRCA	ICGC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation altering degron motif	0.7568
p.G343R	DO52556	BRCA	ICGC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation altering degron motif	0.7568
p.S342P	DO222877	COCA	ICGC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation altering degron motif	0.6752
p.S345P	DO50452	ESAD	ICGC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation rewiring degron network	0.3056
p.L353I	DO50857	LIRI	ICGC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation rewiring degron network	0.0833
p.E331K	DO220856	MELA	ICGC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation rewiring degron network	0.25
p.R338K	DO222843	MELA	ICGC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation altering degron motif	0.7237
p.S345L	SIDM00482	Chronic Myelogenous Leukemia	GDSC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation rewiring degron network	0.3056
p.S345L	ACH-002302	Leukemia	CCLE	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation rewiring degron network	0.3056
p.S345L	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation rewiring degron network	0.3056
p.Q339H	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation altering degron motif	0.647
p.Q339H	ACH-000841	Lung Cancer	CCLE	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation altering degron motif	0.647
p.Q339H	NCI-H2087	lung	COSMIC	DRTNLQVPSGV	DEG_COP1_1	334:344	Mutation altering degron motif	0.647

Kaplan plot for SYT16 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYT16

UniProt ID: Q17RD7

Entrez ID: 83851

Protein name: Synaptotagmin-16 (Chr14Syt) (Synaptotagmin 14-like protein) (Synaptotagmin XIV-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SYT16 in