DegronMD

Uniprot ID: Q17RD7

Source protein: Synaptotagmin-16

Source gene: SYT16

Class: DEG_COP1_1

Location: 334:344

E3 ligase: COP1

DEGRON score: 0.936

ASA_SCORE: 88.7727

COIL: 0.855

CONS_SCORE: 0.3844

DSS_SCORE: 0.5847

HELIX: 0.1107

FCONS_SCORE: 0.8524

RIG_SCORE: 0.6965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G343W	TCGA-55-8506	LUAD	TCGA	DRTNLQVPSGV	DEG_COP1_1	0.7825
p.G343W	DO45390	LUAD	ICGC	DRTNLQVPSGV	DEG_COP1_1	0.7825
p.G343W	ACH-001096	Sarcoma	CCLE	DRTNLQVPSGV	DEG_COP1_1	0.7825
p.E332K	TCGA-D9-A6EC	SKCM	TCGA	DRTNLQVPSGV	DEG_COP1_1	0.2778
p.D334G	TCGA-DD-A4NB	LIHC	TCGA	DRTNLQVPSGV	DEG_COP1_1	0.7198
p.S326F	TCGA-HR-A2OG	SKCM	TCGA	DRTNLQVPSGV	DEG_COP1_1	0.1111
p.S326F	DO37511	SKCM	ICGC	DRTNLQVPSGV	DEG_COP1_1	0.1111
p.E331G	TCGA-S9-A7QW	LGG	TCGA	DRTNLQVPSGV	DEG_COP1_1	0.25
p.E331G	DO50212	LGG	ICGC	DRTNLQVPSGV	DEG_COP1_1	0.25
p.G343R	DO225009	BRCA	ICGC	DRTNLQVPSGV	DEG_COP1_1	0.7568
p.G343R	DO52556	BRCA	ICGC	DRTNLQVPSGV	DEG_COP1_1	0.7568
p.S342P	DO222877	COCA	ICGC	DRTNLQVPSGV	DEG_COP1_1	0.6752
p.S345P	DO50452	ESAD	ICGC	DRTNLQVPSGV	DEG_COP1_1	0.3056
p.L353I	DO50857	LIRI	ICGC	DRTNLQVPSGV	DEG_COP1_1	0.0833
p.E331K	DO220856	MELA	ICGC	DRTNLQVPSGV	DEG_COP1_1	0.25
p.R338K	DO222843	MELA	ICGC	DRTNLQVPSGV	DEG_COP1_1	0.7237
p.S345L	SIDM00482	Chronic Myelogenous Leukemia	GDSC	DRTNLQVPSGV	DEG_COP1_1	0.3056
p.S345L	ACH-002302	Leukemia	CCLE	DRTNLQVPSGV	DEG_COP1_1	0.3056
p.S345L	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	DRTNLQVPSGV	DEG_COP1_1	0.3056
p.Q339H	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	DRTNLQVPSGV	DEG_COP1_1	0.647
p.Q339H	ACH-000841	Lung Cancer	CCLE	DRTNLQVPSGV	DEG_COP1_1	0.647
p.Q339H	NCI-H2087	lung	COSMIC	DRTNLQVPSGV	DEG_COP1_1	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17RD7	Synaptotagmin-16	DEG_COP1_1	334:344	DRTNLQVPSGV	COP1	0.936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons