DegronMD - Q17RQ9(NKPD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A580V	TCGA-A5-A2K3	UCEC	TCGA	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.A580V	DO43899	UCEC	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.R596Q	TCGA-B5-A1MR	UCEC	TCGA	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7329
p.R596Q	DO41758	UCEC	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7329
p.Q586H	DO230326	COCA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.E592K	DO234187	ESAD	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7022
p.R584H	DO233259	GACA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2222
p.A594V	DO233867	GACA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.6936
p.A580E	DO229018	LICA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.A580E	DO229008	LICA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.H605Q	DO50720	ORCA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0833
p.T582M	DO38404	STAD	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1667
p.R588H	DO38376	STAD	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.8244
p.T583I	ACH-000983	Leukemia	CCLE	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944
p.T583I	KCL-22	haematopoietic and lymphoid tissue	COSMIC	HRGKLWPVA	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons