DegronMD

Uniprot ID: Q17RQ9

Source protein: NTPase KAP family P-loop domain-containing protein 1

Source gene: NKPD1

Class: DEG_APCC_DBOX_1

Location: 588:596

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9833

ASA_SCORE: 68.2111

COIL: 0.7676

CONS_SCORE: 0.3863

DSS_SCORE: 0.4422

HELIX: 0.0532

FCONS_SCORE: 1.1877

RIG_SCORE: 0.7844

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R588H	DO38376	STAD	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	0.8244
p.R596Q	TCGA-B5-A1MR	UCEC	TCGA	HRGKLWPVA	DEG_APCC_DBOX_1	0.7329
p.R596Q	DO41758	UCEC	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	0.7329
p.E592K	DO234187	ESAD	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	0.7022
p.A594V	DO233867	GACA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	0.6936
p.Q586H	DO230326	COCA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	0.2778
p.R584H	DO233259	GACA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	0.2222
p.T583I	ACH-000983	Leukemia	CCLE	HRGKLWPVA	DEG_APCC_DBOX_1	0.1944
p.T583I	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	HRGKLWPVA	DEG_APCC_DBOX_1	0.1944
p.T582M	DO38404	STAD	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	0.1667
p.A580V	TCGA-A5-A2K3	UCEC	TCGA	HRGKLWPVA	DEG_APCC_DBOX_1	0.1111
p.A580V	DO43899	UCEC	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	0.1111
p.A580E	DO229018	LICA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	0.1111
p.A580E	DO229008	LICA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	0.1111
p.H605Q	DO50720	ORCA	ICGC	HRGKLWPVA	DEG_APCC_DBOX_1	0.0833

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17RQ9	NTPase KAP family P-loop domain-containing protein 1	DEG_APCC_DBOX_1	588:596	HRGKLWPVA	APC,CDC20,FZR1	0.9833	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons