DegronMD - Q17RW2(COL24A1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K303R	TCGA-16-0848	GBM	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation substituting flanking lysine	0.25
p.K303R	DO12196	GBM	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation substituting flanking lysine	0.25
p.H307Y	TCGA-19-5956	GBM	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.25
p.H307Y	DO13863	GBM	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.25
p.Q308H	TCGA-60-2698	LUSC	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.2778
p.Q308H	DO26469	LUSC	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.2778
p.V322I	TCGA-86-A4JF	LUAD	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.2222
p.V322I	DO45317	LUAD	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.2222
p.R311I	TCGA-BS-A0UF	UCEC	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.8102
p.R311I	DO41488	UCEC	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.8102
p.T300A	TCGA-BS-A0UV	UCEC	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.0556
p.T300A	DO42793	UCEC	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.0556
p.V301A	TCGA-CG-5721	STAD	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.0833
p.V301A	DO38192	STAD	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.0833
p.L317P	TCGA-KU-A66S	HNSC	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.7582
p.L317P	DO44456	HNSC	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.7582
p.S312C	DO227871	BRCA	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.643
p.R304T	DO223492	CLLE	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.1667
p.S312F	SIDM00796	Head and Neck Carcinoma	GDSC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.6871
p.S312F	ACH-000740	Head and Neck Cancer	CCLE	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.6871
p.S312F	A253	salivary gland	COSMIC	SRSQLSSLQ	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.6871

Kaplan plot for COL24A1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL24A1

UniProt ID: Q17RW2

Entrez ID: 255631

Protein name: Collagen alpha-1(XXIV) chain

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for COL24A1 in