DegronMD

Uniprot ID: Q17RW2

Source protein: Collagen alpha-1

Source gene: COL24A1

Class: DEG_APCC_DBOX_1

Location: 310:318

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6642

ASA_SCORE: 81.9222

COIL: 0.7768

CONS_SCORE: 0.2948

DSS_SCORE: 0.4757

HELIX: 0.15

FCONS_SCORE: 0.9134

RIG_SCORE: 0.6798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K303R	TCGA-16-0848	GBM	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	0.25
p.K303R	DO12196	GBM	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.25
p.H307Y	TCGA-19-5956	GBM	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	0.25
p.H307Y	DO13863	GBM	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.25
p.Q308H	TCGA-60-2698	LUSC	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	0.2778
p.Q308H	DO26469	LUSC	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.2778
p.V322I	TCGA-86-A4JF	LUAD	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	0.2222
p.V322I	DO45317	LUAD	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.2222
p.R311I	TCGA-BS-A0UF	UCEC	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	0.8102
p.R311I	DO41488	UCEC	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.8102
p.T300A	TCGA-BS-A0UV	UCEC	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	0.0556
p.T300A	DO42793	UCEC	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.0556
p.V301A	TCGA-CG-5721	STAD	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	0.0833
p.V301A	DO38192	STAD	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.0833
p.L317P	TCGA-KU-A66S	HNSC	TCGA	SRSQLSSLQ	DEG_APCC_DBOX_1	0.7582
p.L317P	DO44456	HNSC	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.7582
p.S312C	DO227871	BRCA	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.643
p.R304T	DO223492	CLLE	ICGC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.1667
p.S312F	SIDM00796	Head and Neck Carcinoma	GDSC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.6871
p.S312F	ACH-000740	Head and Neck Cancer	CCLE	SRSQLSSLQ	DEG_APCC_DBOX_1	0.6871
p.S312F	A253	salivary_gland	COSMIC	SRSQLSSLQ	DEG_APCC_DBOX_1	0.6871

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17RW2	Collagen alpha-1	DEG_APCC_DBOX_1	310:318	SRSQLSSLQ	APC,CDC20,FZR1	0.6642	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons