DegronMD - Q1ED39(KNOP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q220R	TCGA-AP-A1DK	UCEC	TCGA	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.6218
p.Q220R	DO42033	UCEC	ICGC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.6218
p.R206G	TCGA-CD-A4MG	STAD	TCGA	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.0833
p.R206G	DO48009	STAD	ICGC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.0833
p.R206K	TCGA-EY-A215	UCEC	TCGA	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.0833
p.R206K	DO42665	UCEC	ICGC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.0833
p.G222V	DO231596	LINC	ICGC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.3056
p.H219Y	SIDM00455	Pancreatic Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.6118
p.H219Y	SIDM00831	Head and Neck Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.6118
p.H219Y	SIDM00042	Pancreatic Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.6118
p.H219Y	SIDM00104	Mesothelioma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.6118
p.H219Y	SIDM00669	Pancreatic Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.6118
p.H219Y	SIDM00091	Ovarian Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.6118
p.H219Y	SIDM00529	Breast Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.6118
p.H219Y	SIDM00467	Acute Myeloid Leukemia	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.6118
p.I218F	SIDM01451	Pancreatic Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.7415
p.N209S	NCI-H1417	lung	COSMIC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.1667
p.H219N	AN3-CA	endometrium	COSMIC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.7423

Kaplan plot for KNOP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KNOP1

UniProt ID: Q1ED39

Entrez ID: 400506

Protein name: Lysine-rich nucleolar protein 1 (Protein FAM191A) (Testis-specific gene 118 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KNOP1 in