DegronMD

Uniprot ID: Q1ED39

Source protein: Lysine-rich nucleolar protein 1

Source gene: KNOP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 215:221

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8868

ASA_SCORE: 127.5714

COIL: 0.7611

CONS_SCORE: 0.4634

DSS_SCORE: 0.8024

HELIX: 0.1004

FCONS_SCORE: 1.1268

RIG_SCORE: 0.6416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q220R	TCGA-AP-A1DK	UCEC	TCGA	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.6218
p.Q220R	DO42033	UCEC	ICGC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R206G	TCGA-CD-A4MG	STAD	TCGA	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R206G	DO48009	STAD	ICGC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R206K	TCGA-EY-A215	UCEC	TCGA	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R206K	DO42665	UCEC	ICGC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G222V	DO231596	LINC	ICGC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.H219Y	SIDM00455	Pancreatic Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H219Y	SIDM00831	Head and Neck Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H219Y	SIDM00042	Pancreatic Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H219Y	SIDM00104	Mesothelioma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H219Y	SIDM00669	Pancreatic Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H219Y	SIDM00091	Ovarian Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H219Y	SIDM00529	Breast Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H219Y	SIDM00467	Acute Myeloid Leukemia	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.6118
p.I218F	SIDM01451	Pancreatic Carcinoma	GDSC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.7415
p.N209S	NCI-H1417	lung	COSMIC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.H219N	AN3-CA	endometrium	COSMIC	KKKIHQE	LIG_APCC_ABBAyCdc20_2	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q1ED39	Lysine-rich nucleolar protein 1	LIG_APCC_ABBAyCdc20_2	215:221	KKKIHQE	APC,CDC20,FZR1	0.8868	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons