DegronMD - Q1EHB4(SLC5A12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V598A	TCGA-06-5416	GBM	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.6936
p.V598A	DO10880	GBM	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.6936
p.E583K	TCGA-44-4112	LUAD	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.1111
p.E583K	DO26032	LUAD	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.1111
p.R592G	TCGA-A5-A0G2	UCEC	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.7568
p.R592G	DO41235	UCEC	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.7568
p.H597Y	TCGA-AA-3697	COAD	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.6118
p.H597Y	DO8424	COAD	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.6118
p.G589E	TCGA-D3-A2JF	SKCM	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.2778
p.G589E	TCGA-D9-A4Z3	SKCM	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.2778
p.G589E	DO47555	SKCM	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.2778
p.G589E	DO38153	SKCM	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.2778
p.N609S	DO49679	LIAD	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.0556
p.N588K	DO228948	LICA	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.25
p.S584Y	DO229031	LICA	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.1389
p.K604N	DO46443	OV	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation substituting flanking lysine	0.3056
p.G600D	DO47159	RECA	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.3056
p.L595P	DO46933	RECA	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.7582
p.P603S	DO218847	SKCA	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.2222
p.Y608H	SIDM01608	Endometrial Carcinoma	GDSC	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.0833
p.Y608H	ACH-000990	Endometrial/Uterine Cancer	CCLE	RRESLVHVP	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.0833

Kaplan plot for SLC5A12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC5A12

UniProt ID: Q1EHB4

Entrez ID: 159963

Protein name: Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC5A12 in