DegronMD

Uniprot ID: Q1EHB4

Source protein: Sodium-coupled monocarboxylate transporter 2

Source gene: SLC5A12

Class: DEG_APCC_DBOX_1

Location: 591:599

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9276

ASA_SCORE: 91.1556

COIL: 0.7026

CONS_SCORE: 0.2539

DSS_SCORE: 0.5087

HELIX: 0.1299

FCONS_SCORE: 0.9871

RIG_SCORE: 0.7197

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V598A	TCGA-06-5416	GBM	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	0.6936
p.V598A	DO10880	GBM	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.6936
p.E583K	TCGA-44-4112	LUAD	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	0.1111
p.E583K	DO26032	LUAD	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.1111
p.R592G	TCGA-A5-A0G2	UCEC	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	0.7568
p.R592G	DO41235	UCEC	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.7568
p.H597Y	TCGA-AA-3697	COAD	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	0.6118
p.H597Y	DO8424	COAD	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.6118
p.G589E	TCGA-D3-A2JF	SKCM	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	0.2778
p.G589E	TCGA-D9-A4Z3	SKCM	TCGA	RRESLVHVP	DEG_APCC_DBOX_1	0.2778
p.G589E	DO47555	SKCM	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.2778
p.G589E	DO38153	SKCM	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.2778
p.N609S	DO49679	LIAD	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.0556
p.N588K	DO228948	LICA	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.25
p.S584Y	DO229031	LICA	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.1389
p.K604N	DO46443	OV	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.3056
p.G600D	DO47159	RECA	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.3056
p.L595P	DO46933	RECA	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.7582
p.P603S	DO218847	SKCA	ICGC	RRESLVHVP	DEG_APCC_DBOX_1	0.2222
p.Y608H	SIDM01608	Endometrial Carcinoma	GDSC	RRESLVHVP	DEG_APCC_DBOX_1	0.0833
p.Y608H	ACH-000990	Endometrial/Uterine Cancer	CCLE	RRESLVHVP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q1EHB4	Sodium-coupled monocarboxylate transporter 2	DEG_APCC_DBOX_1	591:599	RRESLVHVP	APC,CDC20,FZR1	0.9276	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons