DegronMD - Q2M2I3(FAM83E)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A469P	TCGA-AA-A01R	COAD	TCGA	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.1944
p.A469P	DO7934	COAD	ICGC	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.1944
p.V463A	TCGA-AX-A0J1	UCEC	TCGA	LQEPRGVR	SCF_FBXL2	457:464	Mutation altering degron motif	0.5825
p.V463A	DO41199	UCEC	ICGC	LQEPRGVR	SCF_FBXL2	457:464	Mutation altering degron motif	0.5825
p.R447T	TCGA-CX-7219	HNSC	TCGA	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.0556
p.R447T	DO14910	HNSC	ICGC	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.0556
p.W468L	TCGA-D3-A3CB	SKCM	TCGA	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.2222
p.W468L	DO47386	SKCM	ICGC	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.2222
p.R471W	TCGA-D9-A6EC	SKCM	TCGA	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.1389
p.R471W	DO50291	SKCM	ICGC	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.1389
p.R471W	DO41199	UCEC	ICGC	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.1389
p.F449I	TCGA-EE-A2MC	SKCM	TCGA	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.1111
p.F449I	DO37559	SKCM	ICGC	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.1111
p.V463I	DO233888	GACA	ICGC	LQEPRGVR	SCF_FBXL2	457:464	Mutation altering degron motif	0.5965
p.R471Q	SIDM01961	Pancreatic Carcinoma	GDSC	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.1389
p.A472V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.1111
p.D467N	ACH-002508	Skin Cancer	CCLE	LQEPRGVR	SCF_FBXL2	457:464	Mutation rewiring degron network	0.25

Kaplan plot for FAM83E in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM83E

UniProt ID: Q2M2I3

Entrez ID: 54854

Protein name: Protein FAM83E

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM83E in