DegronMD

Uniprot ID: Q2M2I3

Source protein: Protein FAM83E

Source gene: FAM83E

Class: SCF_FBXL2

Location: 457:464

E3 ligase: FBXL2

DEGRON score: 0.5113

ASA_SCORE: 96.225

COIL: 0.8671

CONS_SCORE: 0.248

DSS_SCORE: 0.5667

HELIX: 0.0665

FCONS_SCORE: 0.8347

RIG_SCORE: 0.6963

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A469P	TCGA-AA-A01R	COAD	TCGA	LQEPRGVR	SCF_FBXL2	0.1944
p.A469P	DO7934	COAD	ICGC	LQEPRGVR	SCF_FBXL2	0.1944
p.V463A	TCGA-AX-A0J1	UCEC	TCGA	LQEPRGVR	SCF_FBXL2	0.5825
p.V463A	DO41199	UCEC	ICGC	LQEPRGVR	SCF_FBXL2	0.5825
p.R447T	TCGA-CX-7219	HNSC	TCGA	LQEPRGVR	SCF_FBXL2	0.0556
p.R447T	DO14910	HNSC	ICGC	LQEPRGVR	SCF_FBXL2	0.0556
p.W468L	TCGA-D3-A3CB	SKCM	TCGA	LQEPRGVR	SCF_FBXL2	0.2222
p.W468L	DO47386	SKCM	ICGC	LQEPRGVR	SCF_FBXL2	0.2222
p.R471W	TCGA-D9-A6EC	SKCM	TCGA	LQEPRGVR	SCF_FBXL2	0.1389
p.R471W	DO50291	SKCM	ICGC	LQEPRGVR	SCF_FBXL2	0.1389
p.R471W	DO41199	UCEC	ICGC	LQEPRGVR	SCF_FBXL2	0.1389
p.F449I	TCGA-EE-A2MC	SKCM	TCGA	LQEPRGVR	SCF_FBXL2	0.1111
p.F449I	DO37559	SKCM	ICGC	LQEPRGVR	SCF_FBXL2	0.1111
p.V463I	DO233888	GACA	ICGC	LQEPRGVR	SCF_FBXL2	0.5965
p.R471Q	SIDM01961	Pancreatic Carcinoma	GDSC	LQEPRGVR	SCF_FBXL2	0.1389
p.A472V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LQEPRGVR	SCF_FBXL2	0.1111
p.D467N	ACH-002508	Skin Cancer	CCLE	LQEPRGVR	SCF_FBXL2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M2I3	Protein FAM83E	SCF_FBXL2	457:464	LQEPRGVR	FBXL2	0.5113	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons