DegronMD - Q2M3C6(TMEM266)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S329G	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.0556
p.S329G	SIDM00433	T-Lymphoblastic Leukemia	GDSC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.0556
p.S329G	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.0556
p.S329G	SIDM00190	Melanoma	GDSC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.0556
p.S329G	SIDM00974	Melanoma	GDSC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.0556
p.S329G	SIDM01050	Biliary Tract Carcinoma	GDSC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.0556
p.S329G	SIDM01715	Non-Cancerous	GDSC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.0556
p.S329G	SIDM00100	Mesothelioma	GDSC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.0556
p.A348V	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.3056
p.A348V	TE-5	oesophagus	COSMIC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.3056
p.V349M	SIDM00901	Endometrial Carcinoma	GDSC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.2778
p.V349M	AN3-CA	endometrium	COSMIC	SSDSGVPEP	DEG_COP1_1	339:347	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons