DegronMD

Uniprot ID: Q2M3C6

Source protein: Transmembrane protein 266

Source gene: TMEM266

Class: DEG_COP1_1

Location: 339:347

E3 ligase: COP1

DEGRON score: 0.9624

ASA_SCORE: 72.2556

COIL: 0.9118

CONS_SCORE: 0.398

DSS_SCORE: 0.428

HELIX: 0.0326

FCONS_SCORE: 0.96

RIG_SCORE: 0.632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S329G	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	SSDSGVPEP	DEG_COP1_1	0.0556
p.S329G	SIDM00433	T-Lymphoblastic Leukemia	GDSC	SSDSGVPEP	DEG_COP1_1	0.0556
p.S329G	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	SSDSGVPEP	DEG_COP1_1	0.0556
p.S329G	SIDM00190	Melanoma	GDSC	SSDSGVPEP	DEG_COP1_1	0.0556
p.S329G	SIDM00974	Melanoma	GDSC	SSDSGVPEP	DEG_COP1_1	0.0556
p.S329G	SIDM01050	Biliary Tract Carcinoma	GDSC	SSDSGVPEP	DEG_COP1_1	0.0556
p.S329G	SIDM01715	Non-Cancerous	GDSC	SSDSGVPEP	DEG_COP1_1	0.0556
p.S329G	SIDM00100	Mesothelioma	GDSC	SSDSGVPEP	DEG_COP1_1	0.0556
p.A348V	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	SSDSGVPEP	DEG_COP1_1	0.3056
p.A348V	TE-5	oesophagus	COSMIC	SSDSGVPEP	DEG_COP1_1	0.3056
p.V349M	SIDM00901	Endometrial Carcinoma	GDSC	SSDSGVPEP	DEG_COP1_1	0.2778
p.V349M	AN3-CA	endometrium	COSMIC	SSDSGVPEP	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M3C6	Transmembrane protein 266	DEG_COP1_1	339:347	SSDSGVPEP	COP1	0.9624	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons