DegronMD - Q2NKX9(C2orf68)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A114T	TCGA-AX-A1CE	UCEC	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.3056
p.A114T	DO42280	UCEC	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.3056
p.I123F	TCGA-BA-5153	HNSC	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.2778
p.I123F	DO15030	HNSC	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.2778
p.V124I	TCGA-BR-4201	STAD	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.25
p.V124I	DO38707	STAD	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.25
p.A114G	TCGA-BR-A4QI	STAD	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.3056
p.A114G	DO38523	STAD	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.3056
p.A114V	TCGA-D1-A1NY	UCEC	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.3056
p.A114V	DO234230	ESAD	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.3056
p.A114V	DO42512	UCEC	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.3056
p.D128N	TCGA-DK-A3WW	BLCA	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.1389
p.D128N	DO481	BLCA	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.1389
p.P130Q	TCGA-EE-A29G	SKCM	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.0833
p.P130Q	TCGA-FS-A1ZK	SKCM	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.0833
p.P130Q	DO37474	SKCM	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.0833
p.P130Q	DO47303	SKCM	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.0833
p.D128G	TCGA-T1-A6J8	LIHC	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.1389
p.D128G	DO219582	LIHC	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.1389
p.E113K	TCGA-VS-A9V5	CESC	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.2778
p.E113K	DO51650	CESC	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.2778
p.P130T	DO233652	GACA	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.0833
p.L110V	DO228194	LICA	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.1944
p.P118Q	DO228978	LICA	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation altering degron motif	0.7035
p.S111Y	DO229022	LICA	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.2222
p.E118D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation altering degron motif	0.5647
p.E118D	ACH-002256	Leukemia	CCLE	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation altering degron motif	0.5647
p.P130A	SIDM00774	Breast Carcinoma	GDSC	DSGEVTS	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C2orf68

UniProt ID: Q2NKX9

Entrez ID: 388969

Protein name: UPF0561 protein C2orf68

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C2orf68 in