DegronMD

Uniprot ID: Q2NKX9

Source protein: UPF0561 protein C2orf68

Source gene: C2orf68

Class: DEG_SCF_TRCP1_1

Location: 115:121

E3 ligase: BTRC

DEGRON score: 0.5652

ASA_SCORE: 65.5857

COIL: 0.5667

CONS_SCORE: 0.573

DSS_SCORE: 0.3835

HELIX: 0.0049

FCONS_SCORE: 1.0019

RIG_SCORE: 0.7579

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A114T	TCGA-AX-A1CE	UCEC	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	0.3056
p.A114T	DO42280	UCEC	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.3056
p.I123F	TCGA-BA-5153	HNSC	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	0.2778
p.I123F	DO15030	HNSC	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.2778
p.V124I	TCGA-BR-4201	STAD	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	0.25
p.V124I	DO38707	STAD	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.25
p.A114G	TCGA-BR-A4QI	STAD	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	0.3056
p.A114G	DO38523	STAD	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.3056
p.A114V	TCGA-D1-A1NY	UCEC	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	0.3056
p.A114V	DO234230	ESAD	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.3056
p.A114V	DO42512	UCEC	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.3056
p.D128N	TCGA-DK-A3WW	BLCA	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	0.1389
p.D128N	DO481	BLCA	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.1389
p.P130Q	TCGA-EE-A29G	SKCM	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	0.0833
p.P130Q	TCGA-FS-A1ZK	SKCM	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	0.0833
p.P130Q	DO37474	SKCM	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.0833
p.P130Q	DO47303	SKCM	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.0833
p.D128G	TCGA-T1-A6J8	LIHC	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	0.1389
p.D128G	DO219582	LIHC	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.1389
p.E113K	TCGA-VS-A9V5	CESC	TCGA	DSGEVTS	DEG_SCF_TRCP1_1	0.2778
p.E113K	DO51650	CESC	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.2778
p.P130T	DO233652	GACA	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.0833
p.L110V	DO228194	LICA	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.1944
p.P118Q	DO228978	LICA	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.7035
p.S111Y	DO229022	LICA	ICGC	DSGEVTS	DEG_SCF_TRCP1_1	0.2222
p.E118D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGEVTS	DEG_SCF_TRCP1_1	0.5647
p.E118D	ACH-002256	Leukemia	CCLE	DSGEVTS	DEG_SCF_TRCP1_1	0.5647
p.P130A	SIDM00774	Breast Carcinoma	GDSC	DSGEVTS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2NKX9	UPF0561 protein C2orf68	DEG_SCF_TRCP1_1	115:121	DSGEVTS	BTRC	0.5652	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGEVTS

Degron related mutations and impact score

Drug responses associated with C2orf68 mutations

All proteins holding degron of DSGEVTS