DegronMD - Q2TBC4(PRICKLE4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E310D	TCGA-AG-A002	READ	TCGA	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.0833
p.E310D	TCGA-BS-A0UV	UCEC	TCGA	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.0833
p.E310D	DO42793	UCEC	ICGC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.0833
p.E310D	SIDM01611	Endometrial Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.0833
p.E310D	ACH-000996	Endometrial/Uterine Cancer	CCLE	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.0833
p.S287L	DO229013	COCA	ICGC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1389
p.S287L	DO229003	COCA	ICGC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1389
p.G293V	DO228986	LICA	ICGC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.3056
p.G293V	SIDM00488	Colorectal Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.3056
p.G293V	SIDM00380	Acute Myeloid Leukemia	GDSC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.3056
p.G293V	SIDM00173	Head and Neck Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.3056
p.A290S	DO229034	LICA	ICGC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.2222
p.P294S	DO45055	LINC	ICGC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.6752
p.R310H	DO219787	UCEC	ICGC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.0833
p.S306R	SIDM00496	Thyroid Gland Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1944
p.S306R	SIDM00375	Head and Neck Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1944
p.S306R	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1944
p.S306R	SIDM01728	Endometrial Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1944
p.S306R	SIDM01735	Biliary Tract Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1944
p.S306R	SIDM01682	Gastric Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1944
p.S306R	SIDM01611	Endometrial Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1944
p.P298S	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.6752
p.P308R	NCI-H1563	lung	COSMIC	PKDTPFST	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.1389

Kaplan plot for PRICKLE4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRICKLE4

UniProt ID: Q2TBC4

Entrez ID: 29964

Protein name: Prickle-like protein 4 (Overexpressed breast tumor protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRICKLE4 in