DegronMD

Uniprot ID: Q2TBC4

Source protein: Prickle-like protein 4

Source gene: PRICKLE4

Class: DEG_SCF_FBW7_1

Location: 294:301

E3 ligase: FBXW7

DEGRON score: 0.9523

ASA_SCORE: 81.15

COIL: 0.825

CONS_SCORE: 0.3124

DSS_SCORE: 0.6453

HELIX: 0.1396

FCONS_SCORE: 0.8153

RIG_SCORE: 0.6563

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P294S	DO45055	LINC	ICGC	PKDTPFST	DEG_SCF_FBW7_1	0.6752
p.P298S	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PKDTPFST	DEG_SCF_FBW7_1	0.6752
p.G293V	DO228986	LICA	ICGC	PKDTPFST	DEG_SCF_FBW7_1	0.3056
p.G293V	SIDM00488	Colorectal Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	0.3056
p.G293V	SIDM00380	Acute Myeloid Leukemia	GDSC	PKDTPFST	DEG_SCF_FBW7_1	0.3056
p.G293V	SIDM00173	Head and Neck Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	0.3056
p.A290S	DO229034	LICA	ICGC	PKDTPFST	DEG_SCF_FBW7_1	0.2222
p.S306R	SIDM00496	Thyroid Gland Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	0.1944
p.S306R	SIDM00375	Head and Neck Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	0.1944
p.S306R	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	0.1944
p.S306R	SIDM01728	Endometrial Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	0.1944
p.S306R	SIDM01735	Biliary Tract Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	0.1944
p.S306R	SIDM01682	Gastric Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	0.1944
p.S306R	SIDM01611	Endometrial Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	0.1944
p.S287L	DO229013	COCA	ICGC	PKDTPFST	DEG_SCF_FBW7_1	0.1389
p.S287L	DO229003	COCA	ICGC	PKDTPFST	DEG_SCF_FBW7_1	0.1389
p.P308R	NCI-H1563	lung	COSMIC	PKDTPFST	DEG_SCF_FBW7_1	0.1389
p.E310D	TCGA-AG-A002	READ	TCGA	PKDTPFST	DEG_SCF_FBW7_1	0.0833
p.E310D	TCGA-BS-A0UV	UCEC	TCGA	PKDTPFST	DEG_SCF_FBW7_1	0.0833
p.E310D	DO42793	UCEC	ICGC	PKDTPFST	DEG_SCF_FBW7_1	0.0833
p.E310D	SIDM01611	Endometrial Carcinoma	GDSC	PKDTPFST	DEG_SCF_FBW7_1	0.0833
p.E310D	ACH-000996	Endometrial/Uterine Cancer	CCLE	PKDTPFST	DEG_SCF_FBW7_1	0.0833
p.R310H	DO219787	UCEC	ICGC	PKDTPFST	DEG_SCF_FBW7_1	0.0833

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Drug responses associated with PRICKLE4 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PKDTPFST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TBC4	Prickle-like protein 4	DEG_SCF_FBW7_1	294:301	PKDTPFST	FBXW7	0.9523	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKDTPFST

Degron related mutations and impact score

Drug responses associated with PRICKLE4 mutations

All proteins holding degron of PKDTPFST