DegronMD - Q2VPJ9(LRRC75B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R265W	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.R265W	SIDM00193	Colorectal Carcinoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.R265W	SIDM01045	Endometrial Carcinoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.R265W	SIDM01146	Gastric Carcinoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.R265W	SIDM00959	Acute Myeloid Leukemia	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.R265W	CMK	haematopoietic and lymphoid tissue	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.R265W	EN	endometrium	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.R265W	SNU-81	large intestine	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.R265W	LU-99A	lung	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.R265W	NCI-SNU-1	stomach	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.R266W	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.25
p.R266W	HCC-44	lung	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.25
p.G262D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.1389
p.G262D	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.1389
p.E278K	SIDM01114	Non-Cancerous	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.3056
p.E278K	PWR-1E	prostate	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.3056
p.R265Q	SIDM00244	Neuroblastoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.R265Q	NB69	autonomic ganglia	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.2222
p.L282F	SIDM00011	Melanoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	269:277	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC75B

UniProt ID: Q2VPJ9

Entrez ID: 388886

Protein name: Leucine-rich repeat-containing protein 75B (Leucine-rich repeat-containing protein FAM211B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC75B in