DegronMD

Uniprot ID: Q2VPJ9

Source protein: Leucine-rich repeat-containing protein 75B

Source gene: LRRC75B

Class: DEG_APCC_DBOX_1

Location: 269:277

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9896

ASA_SCORE: 67.5667

COIL: 0.687

CONS_SCORE: 0.7617

DSS_SCORE: 0.3367

HELIX: 0.1317

FCONS_SCORE: 1.2127

RIG_SCORE: 0.7563

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R265W	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.R265W	SIDM00193	Colorectal Carcinoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.R265W	SIDM01045	Endometrial Carcinoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.R265W	SIDM01146	Gastric Carcinoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.R265W	SIDM00959	Acute Myeloid Leukemia	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.R265W	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.R265W	EN	endometrium	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.R265W	SNU-81	large_intestine	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.R265W	LU-99A	lung	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.R265W	NCI-SNU-1	stomach	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.R266W	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	0.25
p.R266W	HCC-44	lung	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	0.25
p.G262D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	0.1389
p.G262D	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	0.1389
p.E278K	SIDM01114	Non-Cancerous	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	0.3056
p.E278K	PWR-1E	prostate	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	0.3056
p.R265Q	SIDM00244	Neuroblastoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.R265Q	NB69	autonomic_ganglia	COSMIC	QRTSLPTIY	DEG_APCC_DBOX_1	0.2222
p.L282F	SIDM00011	Melanoma	GDSC	QRTSLPTIY	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2VPJ9	Leucine-rich repeat-containing protein 75B	DEG_APCC_DBOX_1	269:277	QRTSLPTIY	APC,CDC20,FZR1	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons