DegronMD - Q2Y0W8(SLC4A8)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q223P	TCGA-46-3769	LUSC	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.2222
p.K219N	TCGA-69-7979	LUAD	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation substituting flanking lysine	0.2222
p.K226N	TCGA-AG-A002	READ	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.R236C	TCGA-AP-A1DV	UCEC	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.R236C	TCGA-FW-A3R5	SKCM	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.R236H	TCGA-AX-A2HD	UCEC	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.R236H	ACH-001991	Primary	CCLE	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.K227N	TCGA-B6-A0IJ	BRCA	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.5806
p.Q223H	TCGA-CA-6717	COAD	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.2222
p.H222Y	TCGA-W3-AA1R	SKCM	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1944
p.E224K	DO218984	BLCA	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.25
p.I241V	DO219694	KIRP	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1667
p.A245S	DO229026	LICA	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.P227F	DO222420	MELA	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.7897
p.P242S	DO222875	MELA	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1389
p.P242S	DO37603	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1389
p.P242S	DO37571	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1389
p.M238I	DO37611	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.25
p.M238I	DO47281	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.25
p.M238I	DO48601	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.25
p.P227H	DO37715	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.7694
p.V241A	SIDM01175	Other Sarcomas	GDSC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1667
p.V241A	ACH-002309	Sarcoma	CCLE	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1667
p.V241A	SW684	soft tissue	COSMIC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1667
p.R236L	SIDM00592	Oral Cavity Carcinoma	GDSC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.R236L	ACH-002244	Head and Neck Cancer	CCLE	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.R236L	HO-1-N-1	salivary gland	COSMIC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.F237L	A431	skin	COSMIC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation blocking phosphorylation signal	0.7222
p.F237L	HCC1937	breast	COSMIC	KRNNLIPIV	DEG_APCC_DBOX_1	227:235	Mutation blocking phosphorylation signal	0.7222

Kaplan plot for SLC4A8 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC4A8

UniProt ID: Q2Y0W8

Entrez ID: 9498

Protein name: Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SLC4A8 in