DegronMD

Uniprot ID: Q2Y0W8

Source protein: Electroneutral sodium bicarbonate exchanger 1

Source gene: SLC4A8

Class: DEG_APCC_DBOX_1

Location: 227:235

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9551

ASA_SCORE: 100.3111

COIL: 0.811

CONS_SCORE: 0.2094

DSS_SCORE: 0.5357

HELIX: 0.1074

FCONS_SCORE: 0.9223

RIG_SCORE: 0.7595

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q223P	TCGA-46-3769	LUSC	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	0.2222
p.K219N	TCGA-69-7979	LUAD	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	0.2222
p.K226N	TCGA-AG-A002	READ	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	0.3056
p.R236C	TCGA-AP-A1DV	UCEC	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	0.3056
p.R236C	TCGA-FW-A3R5	SKCM	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	0.3056
p.R236H	TCGA-AX-A2HD	UCEC	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	0.3056
p.R236H	ACH-001991	Primary	CCLE	KRNNLIPIV	DEG_APCC_DBOX_1	0.3056
p.K227N	TCGA-B6-A0IJ	BRCA	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	0.5806
p.Q223H	TCGA-CA-6717	COAD	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	0.2222
p.H222Y	TCGA-W3-AA1R	SKCM	TCGA	KRNNLIPIV	DEG_APCC_DBOX_1	0.1944
p.E224K	DO218984	BLCA	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	0.25
p.I241V	DO219694	KIRP	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	0.1667
p.A245S	DO229026	LICA	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	0.0556
p.P227F	DO222420	MELA	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	0.7897
p.P242S	DO222875	MELA	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	0.1389
p.P242S	DO37603	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	0.1389
p.P242S	DO37571	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	0.1389
p.M238I	DO37611	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	0.25
p.M238I	DO47281	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	0.25
p.M238I	DO48601	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	0.25
p.P227H	DO37715	SKCM	ICGC	KRNNLIPIV	DEG_APCC_DBOX_1	0.7694
p.V241A	SIDM01175	Other Sarcomas	GDSC	KRNNLIPIV	DEG_APCC_DBOX_1	0.1667
p.V241A	ACH-002309	Sarcoma	CCLE	KRNNLIPIV	DEG_APCC_DBOX_1	0.1667
p.V241A	SW684	soft_tissue	COSMIC	KRNNLIPIV	DEG_APCC_DBOX_1	0.1667
p.R236L	SIDM00592	Oral Cavity Carcinoma	GDSC	KRNNLIPIV	DEG_APCC_DBOX_1	0.3056
p.R236L	ACH-002244	Head and Neck Cancer	CCLE	KRNNLIPIV	DEG_APCC_DBOX_1	0.3056
p.R236L	HO-1-N-1	salivary_gland	COSMIC	KRNNLIPIV	DEG_APCC_DBOX_1	0.3056
p.F237L	A431	skin	COSMIC	KRNNLIPIV	DEG_APCC_DBOX_1	0.7222
p.F237L	HCC1937	breast	COSMIC	KRNNLIPIV	DEG_APCC_DBOX_1	0.7222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRNNLIPIV

Degron related mutations and impact score

Drug responses associated with SLC4A8 mutations

All proteins holding degron of KRNNLIPIV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2Y0W8	Electroneutral sodium bicarbonate exchanger 1	DEG_APCC_DBOX_1	227:235	KRNNLIPIV	APC,CDC20,FZR1	0.9551	More...