DegronMD - Q3MIN7(RGL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F380V	TCGA-AX-A05Z	UCEC	TCGA	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0556
p.F380V	DO40884	UCEC	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0556
p.F394S	TCGA-BR-8060	STAD	TCGA	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.7982
p.F394S	DO38205	STAD	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.7982
p.E391Q	TCGA-CN-4723	HNSC	TCGA	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.5633
p.E391Q	DO14830	HNSC	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.5633
p.S402F	DO234345	ESAD	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1667
p.N384K	DO228971	LICA	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1667
p.S388R	DO229018	LICA	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.2778
p.E405Q	DO46513	OV	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0833
p.E405K	DO229456	SKCA	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0833
p.E404K	SIDM00140	Melanoma	GDSC	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1111
p.E404K	ACH-000968	Skin Cancer	CCLE	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1111
p.E404K	COLO-792	skin	COSMIC	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1111
p.E391D	SIDM01518	Oral Cavity Carcinoma	GDSC	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.5647
p.E391D	ACH-000771	Head and Neck Cancer	CCLE	REILFQE	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.5647

Kaplan plot for RGL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGL3

UniProt ID: Q3MIN7

Entrez ID: 57139

Protein name: Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGL3 in