DegronMD

Uniprot ID: Q3MIN7

Source protein: Ral guanine nucleotide dissociation stimulator-like 3

Source gene: RGL3

Class: LIG_APCC_ABBAyCdc20_2

Location: 390:396

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9918

ASA_SCORE: 68.3714

COIL: 0.1081

CONS_SCORE: 0.4418

DSS_SCORE: 0.6467

HELIX: 0.8826

FCONS_SCORE: 1.3994

RIG_SCORE: 0.7512

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F380V	TCGA-AX-A05Z	UCEC	TCGA	REILFQE	LIG_APCC_ABBAyCdc20_2	0.0556
p.F380V	DO40884	UCEC	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	0.0556
p.F394S	TCGA-BR-8060	STAD	TCGA	REILFQE	LIG_APCC_ABBAyCdc20_2	0.7982
p.F394S	DO38205	STAD	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	0.7982
p.E391Q	TCGA-CN-4723	HNSC	TCGA	REILFQE	LIG_APCC_ABBAyCdc20_2	0.5633
p.E391Q	DO14830	HNSC	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	0.5633
p.S402F	DO234345	ESAD	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N384K	DO228971	LICA	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S388R	DO229018	LICA	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E405Q	DO46513	OV	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E405K	DO229456	SKCA	ICGC	REILFQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E404K	SIDM00140	Melanoma	GDSC	REILFQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E404K	ACH-000968	Skin Cancer	CCLE	REILFQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E404K	COLO-792	skin	COSMIC	REILFQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E391D	SIDM01518	Oral Cavity Carcinoma	GDSC	REILFQE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E391D	ACH-000771	Head and Neck Cancer	CCLE	REILFQE	LIG_APCC_ABBAyCdc20_2	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3MIN7	Ral guanine nucleotide dissociation stimulator-like 3	LIG_APCC_ABBAyCdc20_2	390:396	REILFQE	APC,CDC20,FZR1	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons