DegronMD - Q3MJ13(WDR72)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q13E	TCGA-22-5471	LUSC	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.2222
p.Q13E	DO27500	LUSC	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.2222
p.S19N	TCGA-BR-7703	STAD	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.0556
p.S19N	DO38232	STAD	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.0556
p.S19N	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.0556
p.S4F	TCGA-EE-A29S	SKCM	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.7982
p.S4F	DO220878	MELA	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.7982
p.S4F	DO37936	SKCM	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.7982
p.G12R	TCGA-EE-A3JD	SKCM	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.25
p.G12R	DO50299	SKCM	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.25
p.W11C	TCGA-ER-A19P	SKCM	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.2778
p.W11C	DO47623	SKCM	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.2778
p.S4Y	TCGA-XQ-A8TA	PRAD	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.712
p.S4Y	DO223662	PRAD	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.712
p.K14T	DO223124	ESCA	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation substituting flanking lysine	0.3056
p.Q6K	DO228424	MALY	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.5833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons