DegronMD

Uniprot ID: Q3MJ13

Source protein: WD repeat-containing protein 72

Source gene: WDR72

Class: DEG_APCC_DBOX_1

Location: 1:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8498

ASA_SCORE: 63.9111

COIL: 0.5488

CONS_SCORE: 0.4942

DSS_SCORE: 0.6157

HELIX: 0.0119

FCONS_SCORE: 0.8768

RIG_SCORE: 0.8091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q13E	TCGA-22-5471	LUSC	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	0.2222
p.Q13E	DO27500	LUSC	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	0.2222
p.S19N	TCGA-BR-7703	STAD	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	0.0556
p.S19N	DO38232	STAD	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	0.0556
p.S19N	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	MRTSLQAVA	DEG_APCC_DBOX_1	0.0556
p.S4F	TCGA-EE-A29S	SKCM	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	0.7982
p.S4F	DO220878	MELA	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	0.7982
p.S4F	DO37936	SKCM	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	0.7982
p.G12R	TCGA-EE-A3JD	SKCM	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	0.25
p.G12R	DO50299	SKCM	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	0.25
p.W11C	TCGA-ER-A19P	SKCM	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	0.2778
p.W11C	DO47623	SKCM	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	0.2778
p.S4Y	TCGA-XQ-A8TA	PRAD	TCGA	MRTSLQAVA	DEG_APCC_DBOX_1	0.712
p.S4Y	DO223662	PRAD	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	0.712
p.K14T	DO223124	ESCA	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	0.3056
p.Q6K	DO228424	MALY	ICGC	MRTSLQAVA	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3MJ13	WD repeat-containing protein 72	DEG_APCC_DBOX_1	1:9	MRTSLQAVA	APC,CDC20,FZR1	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons