DegronMD - Q3ZCQ2(ANXA2R)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S124I	TCGA-AP-A059	UCEC	TCGA	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.2778
p.S124I	DO41361	UCEC	ICGC	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.2778
p.A110T	TCGA-CG-4460	STAD	TCGA	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.2222
p.A110T	DO38427	STAD	ICGC	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.2222
p.P129S	TCGA-D3-A1Q6	SKCM	TCGA	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.1389
p.P129S	DO37450	SKCM	ICGC	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.1389
p.Q119R	DO234285	ESAD	ICGC	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.6218
p.Q109K	DO229034	LICA	ICGC	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.1944
p.E106Q	SIDM01148	Plasma Cell Myeloma	GDSC	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.1111
p.E106Q	ACH-000050	Myeloma	CCLE	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.1111
p.E106Q	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.1111
p.S125G	SIDM01570	Ovarian Carcinoma	GDSC	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.25
p.S125G	ACH-000324	Ovarian Cancer	CCLE	DRLRLQQLP	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons