DegronMD

Uniprot ID: Q3ZCQ2

Source protein: Annexin-2 receptor

Source gene: ANXA2R

Class: DEG_APCC_DBOX_1

Location: 114:122

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.933

ASA_SCORE: 88.2444

COIL: 0.6406

CONS_SCORE: 0.597

DSS_SCORE: 0.5652

HELIX: 0.3198

FCONS_SCORE: 1.066

RIG_SCORE: 0.7445

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S124I	TCGA-AP-A059	UCEC	TCGA	DRLRLQQLP	DEG_APCC_DBOX_1	0.2778
p.S124I	DO41361	UCEC	ICGC	DRLRLQQLP	DEG_APCC_DBOX_1	0.2778
p.A110T	TCGA-CG-4460	STAD	TCGA	DRLRLQQLP	DEG_APCC_DBOX_1	0.2222
p.A110T	DO38427	STAD	ICGC	DRLRLQQLP	DEG_APCC_DBOX_1	0.2222
p.P129S	TCGA-D3-A1Q6	SKCM	TCGA	DRLRLQQLP	DEG_APCC_DBOX_1	0.1389
p.P129S	DO37450	SKCM	ICGC	DRLRLQQLP	DEG_APCC_DBOX_1	0.1389
p.Q119R	DO234285	ESAD	ICGC	DRLRLQQLP	DEG_APCC_DBOX_1	0.6218
p.Q109K	DO229034	LICA	ICGC	DRLRLQQLP	DEG_APCC_DBOX_1	0.1944
p.E106Q	SIDM01148	Plasma Cell Myeloma	GDSC	DRLRLQQLP	DEG_APCC_DBOX_1	0.1111
p.E106Q	ACH-000050	Myeloma	CCLE	DRLRLQQLP	DEG_APCC_DBOX_1	0.1111
p.E106Q	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	DRLRLQQLP	DEG_APCC_DBOX_1	0.1111
p.S125G	SIDM01570	Ovarian Carcinoma	GDSC	DRLRLQQLP	DEG_APCC_DBOX_1	0.25
p.S125G	ACH-000324	Ovarian Cancer	CCLE	DRLRLQQLP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3ZCQ2	Annexin-2 receptor	DEG_APCC_DBOX_1	114:122	DRLRLQQLP	APC,CDC20,FZR1	0.933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons