DegronMD - Q494R4(CCDC153)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L210I	TCGA-A5-A0G2	UCEC	TCGA	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation rewiring degron network	0.1111
p.L210I	DO41235	UCEC	ICGC	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation rewiring degron network	0.1111
p.K189N	TCGA-EE-A3AD	SKCM	TCGA	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation substituting flanking lysine	0.2222
p.K189N	DO37707	SKCM	ICGC	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation substituting flanking lysine	0.2222
p.R193C	TCGA-TQ-A7RH	LGG	TCGA	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation rewiring degron network	0.2222
p.R193C	DO219849	LGG	ICGC	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation rewiring degron network	0.2222
p.Q192K	DO228923	LICA	ICGC	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation rewiring degron network	0.1944
p.R193S	DO229008	LICA	ICGC	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation rewiring degron network	0.2222
p.L197V	DO231155	LUSC	ICGC	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation altering degron motif	0.5654
p.P208L	DO222837	MELA	ICGC	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation rewiring degron network	0.1667
p.T198P	DO48539	PAEN	ICGC	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation altering degron motif	0.7031
p.P205S	SIDM02015	Colorectal Carcinoma	GDSC	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation rewiring degron network	0.25
p.R193H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LTPPGS	DEG_SCF_FBW7_1	197:202	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons