DegronMD

Uniprot ID: Q494R4

Source protein: Coiled-coil domain-containing protein 153

Source gene: CCDC153

Class: DEG_SCF_FBW7_1

Location: 197:202

E3 ligase: FBXW7

DEGRON score: 0.8823

ASA_SCORE: 49.0667

COIL: 0.894

CONS_SCORE: 0.4445

DSS_SCORE: 0.7803

HELIX: 0.0725

FCONS_SCORE: 0.9386

RIG_SCORE: 0.588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L210I	TCGA-A5-A0G2	UCEC	TCGA	LTPPGS	DEG_SCF_FBW7_1	0.1111
p.L210I	DO41235	UCEC	ICGC	LTPPGS	DEG_SCF_FBW7_1	0.1111
p.K189N	TCGA-EE-A3AD	SKCM	TCGA	LTPPGS	DEG_SCF_FBW7_1	0.2222
p.K189N	DO37707	SKCM	ICGC	LTPPGS	DEG_SCF_FBW7_1	0.2222
p.R193C	TCGA-TQ-A7RH	LGG	TCGA	LTPPGS	DEG_SCF_FBW7_1	0.2222
p.R193C	DO219849	LGG	ICGC	LTPPGS	DEG_SCF_FBW7_1	0.2222
p.Q192K	DO228923	LICA	ICGC	LTPPGS	DEG_SCF_FBW7_1	0.1944
p.R193S	DO229008	LICA	ICGC	LTPPGS	DEG_SCF_FBW7_1	0.2222
p.L197V	DO231155	LUSC	ICGC	LTPPGS	DEG_SCF_FBW7_1	0.5654
p.P208L	DO222837	MELA	ICGC	LTPPGS	DEG_SCF_FBW7_1	0.1667
p.T198P	DO48539	PAEN	ICGC	LTPPGS	DEG_SCF_FBW7_1	0.7031
p.P205S	SIDM02015	Colorectal Carcinoma	GDSC	LTPPGS	DEG_SCF_FBW7_1	0.25
p.R193H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LTPPGS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q494R4	Coiled-coil domain-containing protein 153	DEG_SCF_FBW7_1	197:202	LTPPGS	FBXW7	0.8823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons