DegronMD - Q495W5(FUT11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E439Q	TCGA-D8-A1JA	BRCA	TCGA	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.1389
p.E439Q	DO2819	BRCA	ICGC	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.1389
p.H418Y	TCGA-EE-A29E	SKCM	TCGA	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.1944
p.H418Y	DO37831	SKCM	ICGC	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.1944
p.F434V	TCGA-EO-A22R	UCEC	TCGA	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.2778
p.F434V	DO42713	UCEC	ICGC	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.2778
p.P432H	TCGA-EY-A215	UCEC	TCGA	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation altering degron motif	0.7694
p.P432H	DO42665	UCEC	ICGC	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation altering degron motif	0.7694
p.G433D	SIDM00683	Prostate Carcinoma	GDSC	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.3056
p.G433D	LNCaP-Clone-FGC	prostate	COSMIC	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.3056
p.A420T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.25
p.A420T	ACH-001737	Leukemia	CCLE	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.25
p.A420T	ACH-002222	Leukemia	CCLE	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.25
p.A420T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.25
p.H418R	ACH-001510	Head and Neck Cancer	CCLE	SHMDCPVPTP	DEG_COP1_1	423:432	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons