DegronMD

Uniprot ID: Q495W5

Source protein: Alpha-

Source gene: FUT11

Class: DEG_COP1_1

Location: 423:432

E3 ligase: COP1

DEGRON score: 0.9822

ASA_SCORE: 53.5

COIL: 0.8207

CONS_SCORE: 0.391

DSS_SCORE: 0.5785

HELIX: 0.0838

FCONS_SCORE: 1.16

RIG_SCORE: 0.6566

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E439Q	TCGA-D8-A1JA	BRCA	TCGA	SHMDCPVPTP	DEG_COP1_1	0.1389
p.E439Q	DO2819	BRCA	ICGC	SHMDCPVPTP	DEG_COP1_1	0.1389
p.H418Y	TCGA-EE-A29E	SKCM	TCGA	SHMDCPVPTP	DEG_COP1_1	0.1944
p.H418Y	DO37831	SKCM	ICGC	SHMDCPVPTP	DEG_COP1_1	0.1944
p.F434V	TCGA-EO-A22R	UCEC	TCGA	SHMDCPVPTP	DEG_COP1_1	0.2778
p.F434V	DO42713	UCEC	ICGC	SHMDCPVPTP	DEG_COP1_1	0.2778
p.P432H	TCGA-EY-A215	UCEC	TCGA	SHMDCPVPTP	DEG_COP1_1	0.7694
p.P432H	DO42665	UCEC	ICGC	SHMDCPVPTP	DEG_COP1_1	0.7694
p.G433D	SIDM00683	Prostate Carcinoma	GDSC	SHMDCPVPTP	DEG_COP1_1	0.3056
p.G433D	LNCaP-Clone-FGC	prostate	COSMIC	SHMDCPVPTP	DEG_COP1_1	0.3056
p.A420T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	SHMDCPVPTP	DEG_COP1_1	0.25
p.A420T	ACH-001737	Leukemia	CCLE	SHMDCPVPTP	DEG_COP1_1	0.25
p.A420T	ACH-002222	Leukemia	CCLE	SHMDCPVPTP	DEG_COP1_1	0.25
p.A420T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	SHMDCPVPTP	DEG_COP1_1	0.25
p.H418R	ACH-001510	Head and Neck Cancer	CCLE	SHMDCPVPTP	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q495W5	Alpha-	DEG_COP1_1	423:432	SHMDCPVPTP	COP1	0.9822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons