DegronMD - Q496F6(CD300E)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A141T	TCGA-2G-AAFE	TGCT	TCGA	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.2222
p.T138I	TCGA-44-7669	LUAD	TCGA	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.3056
p.E159K	TCGA-A3-3316	KIRC	TCGA	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation altering degron motif	0.7022
p.S156N	TCGA-AZ-6598	COAD	TCGA	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation altering degron motif	0.7069
p.V125M	TCGA-CJ-4913	KIRC	TCGA	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1667
p.S128F	TCGA-EB-A97M	SKCM	TCGA	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.25
p.L169F	TCGA-EE-A3AG	SKCM	TCGA	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.0556
p.L155F	TCGA-FR-A8YD	SKCM	TCGA	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation altering degron motif	0.587
p.R153Q	TCGA-GF-A6C9	SKCM	TCGA	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.3056
p.R153Q	SIDM00003	Melanoma	GDSC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.3056
p.R153Q	M14	skin	COSMIC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.3056
p.R162M	DO48440	BLCA	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.25
p.R144H	DO8730	COAD	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.0556
p.R144H	DO8730	COAD	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1389
p.D145N	DO233837	GACA	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.0833
p.D145N	DO233837	GACA	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1111
p.D145N	DO10880	GBM	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.0833
p.D145N	DO10880	GBM	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1111
p.D145N	DO222413	MELA	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.0833
p.D145N	DO222413	MELA	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1111
p.D145N	DO37635	SKCM	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.0833
p.D145N	DO37635	SKCM	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1111
p.D145N	DO41644	UCEC	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.0833
p.D145N	DO41644	UCEC	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1111
p.D145N	DO43971	UCEC	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.0833
p.D145N	DO43971	UCEC	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1111
p.V152M	DO20377	KIRC	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.2778
p.T165I	DO25262	LUAD	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.1667
p.P146T	DO25396	LUAD	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.1111
p.P146T	DO25396	LUAD	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.0833
p.L121V	DO23678	LUAD	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.0556
p.D125Y	DO24920	LUAD	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1667
p.G127V	DO26432	LUSC	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.2222
p.G127R	DO37659	SKCM	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.2222
p.W137C	DO37575	SKCM	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7
p.S155F	DO50298	SKCM	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation altering degron motif	0.7982
p.P146L	DO51234	SKCM	ICGC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.1111
p.P146L	DO51234	SKCM	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.0833
p.S141L	DO51295	SKCM	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.2222
p.S141L	ACH-000935	Colon/Colorectal Cancer	CCLE	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.2222
p.K132T	DO47813	STAD	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7306
p.D140E	DO41758	UCEC	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.25
p.D140E	DO42793	UCEC	ICGC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.25
p.N164S	SIDM01951	Colorectal Carcinoma	GDSC	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.1944
p.P140S	SIDM00393	Gastric Carcinoma	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.25
p.P140S	SIDM00087	Plasma Cell Myeloma	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.25
p.P140S	SIDM00309	Mesothelioma	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.25
p.T133A	SIDM00393	Gastric Carcinoma	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7139
p.T133A	SIDM00087	Plasma Cell Myeloma	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7139
p.T133A	SIDM00854	Burkitt's Lymphoma	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7139
p.T133A	SIDM00694	Other Solid Cancers	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7139
p.T133A	SIDM00309	Mesothelioma	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7139
p.T133A	SIDM00863	Burkitt's Lymphoma	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7139
p.T133A	SIDM00808	Burkitt's Lymphoma	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7139
p.T133A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7139
p.T133A	SIDM01254	Burkitt's Lymphoma	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7139
p.D121Y	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.0556
p.V136L	ACH-000893	Lung Cancer	CCLE	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.6765
p.D124V	ACH-001107	Pancreatic Cancer	CCLE	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1389
p.D145Y	ACH-001318	Liver Cancer	CCLE	NLSTGE	DEG_Kelch_Keap1_1	154:159	Mutation rewiring degron network	0.0833
p.D145Y	ACH-001318	Liver Cancer	CCLE	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1111
p.V138I	ACH-001844	Bile Duct Cancer	CCLE	ITTPRRT	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD300E

UniProt ID: Q496F6

Entrez ID: 342510

Protein name: CMRF35-like molecule 2 (CLM-2) (CD300 antigen-like family member E) (CMRF35-A5) (Immune receptor expressed on myeloid cells 2) (IREM-2) (Polymeric immunoglobulin receptor 2) (PIgR-2) (PIgR2) (Poly-Ig receptor 2) (CD antigen CD300e)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD300E in