DegronMD

Uniprot ID: Q496F6

Source protein: CMRF35-like molecule 2

Source gene: CD300E

Class: DEG_Kelch_Keap1_1

Location: 154:159

E3 ligase: KEAP1

DEGRON score: 0.6181

ASA_SCORE: 85.6167

COIL: 0.7908

CONS_SCORE: 0.4481

DSS_SCORE: 0.2619

HELIX: 0.029

FCONS_SCORE: 1.2108

RIG_SCORE: 0.7357

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E159K	TCGA-A3-3316	KIRC	TCGA	NLSTGE	DEG_Kelch_Keap1_1	0.7022
p.S156N	TCGA-AZ-6598	COAD	TCGA	NLSTGE	DEG_Kelch_Keap1_1	0.7069
p.L169F	TCGA-EE-A3AG	SKCM	TCGA	NLSTGE	DEG_Kelch_Keap1_1	0.0556
p.L155F	TCGA-FR-A8YD	SKCM	TCGA	NLSTGE	DEG_Kelch_Keap1_1	0.587
p.R153Q	TCGA-GF-A6C9	SKCM	TCGA	NLSTGE	DEG_Kelch_Keap1_1	0.3056
p.R153Q	SIDM00003	Melanoma	GDSC	NLSTGE	DEG_Kelch_Keap1_1	0.3056
p.R153Q	M14	skin	COSMIC	NLSTGE	DEG_Kelch_Keap1_1	0.3056
p.R162M	DO48440	BLCA	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.25
p.R144H	DO8730	COAD	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.0556
p.D145N	DO233837	GACA	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.0833
p.D145N	DO10880	GBM	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.0833
p.D145N	DO222413	MELA	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.0833
p.D145N	DO37635	SKCM	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.0833
p.D145N	DO41644	UCEC	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.0833
p.D145N	DO43971	UCEC	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.0833
p.V152M	DO20377	KIRC	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.2778
p.T165I	DO25262	LUAD	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.1667
p.P146T	DO25396	LUAD	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.1111
p.S155F	DO50298	SKCM	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.7982
p.P146L	DO51234	SKCM	ICGC	NLSTGE	DEG_Kelch_Keap1_1	0.1111
p.N164S	SIDM01951	Colorectal Carcinoma	GDSC	NLSTGE	DEG_Kelch_Keap1_1	0.1944
p.D145Y	ACH-001318	Liver Cancer	CCLE	NLSTGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q496F6	CMRF35-like molecule 2	DEG_Kelch_Keap1_1	154:159	NLSTGE	KEAP1	0.6181	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons