DegronMD - Q49A88(CCDC14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N129D	TCGA-DI-A1BU	UCEC	TCGA	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.3056
p.N129D	DO42023	UCEC	ICGC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.3056
p.E132K	DO44384	CESC	ICGC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.2222
p.A129E	DO229038	LICA	ICGC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.3056
p.I133M	SIDM00437	Acute Myeloid Leukemia	GDSC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1944
p.I133M	SIDM00584	Osteosarcoma	GDSC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1944
p.I133M	SIDM00282	Colorectal Carcinoma	GDSC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1944
p.I133M	SIDM00549	B-Lymphoblastic Leukemia	GDSC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1944
p.I133M	SIDM00579	Neuroblastoma	GDSC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1944
p.I133M	LC4-1	haematopoietic and lymphoid tissue	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1944
p.I133M	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1944
p.I133M	CW-2	large intestine	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1944
p.I133M	HuO-3N1	bone	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1944
p.I133M	NB(TU)1-10	autonomic ganglia	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1944
p.D117G	SIDM00183	Small Cell Lung Carcinoma	GDSC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1667
p.D117G	ACH-002154	Lung Cancer	CCLE	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1667
p.D117G	LB647-SCLC	lung	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.1667
p.I126M	NB(TU)1-10	autonomic ganglia	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation altering degron motif	0.7618
p.I126M	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation altering degron motif	0.7618
p.I126M	LC4-1	haematopoietic and lymphoid tissue	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation altering degron motif	0.7618
p.I126M	CW-2	large intestine	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation altering degron motif	0.7618
p.I126M	HuO-3N1	bone	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation altering degron motif	0.7618
p.Q128E	HT-1197	urinary tract	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation altering degron motif	0.6744
p.S137L	CPC-N	lung	COSMIC	DSGSET	DEG_SCF_TRCP1_1	123:128	Mutation rewiring degron network	0.0833

Kaplan plot for CCDC14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC14

UniProt ID: Q49A88

Entrez ID: 64770

Protein name: Coiled-coil domain-containing protein 14

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC14 in