DegronMD

Uniprot ID: Q49A88

Source protein: Coiled-coil domain-containing protein 14

Source gene: CCDC14

Class: DEG_SCF_TRCP1_1

Location: 123:128

E3 ligase: BTRC

DEGRON score: 0.97

ASA_SCORE: 88.2

COIL: 0.8772

CONS_SCORE: 0.336

DSS_SCORE: 0.4767

HELIX: 0.0985

FCONS_SCORE: 0.7023

RIG_SCORE: 0.668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N129D	TCGA-DI-A1BU	UCEC	TCGA	DSGSET	DEG_SCF_TRCP1_1	0.3056
p.N129D	DO42023	UCEC	ICGC	DSGSET	DEG_SCF_TRCP1_1	0.3056
p.E132K	DO44384	CESC	ICGC	DSGSET	DEG_SCF_TRCP1_1	0.2222
p.A129E	DO229038	LICA	ICGC	DSGSET	DEG_SCF_TRCP1_1	0.3056
p.I133M	SIDM00437	Acute Myeloid Leukemia	GDSC	DSGSET	DEG_SCF_TRCP1_1	0.1944
p.I133M	SIDM00584	Osteosarcoma	GDSC	DSGSET	DEG_SCF_TRCP1_1	0.1944
p.I133M	SIDM00282	Colorectal Carcinoma	GDSC	DSGSET	DEG_SCF_TRCP1_1	0.1944
p.I133M	SIDM00549	B-Lymphoblastic Leukemia	GDSC	DSGSET	DEG_SCF_TRCP1_1	0.1944
p.I133M	SIDM00579	Neuroblastoma	GDSC	DSGSET	DEG_SCF_TRCP1_1	0.1944
p.I133M	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.1944
p.I133M	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.1944
p.I133M	CW-2	large_intestine	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.1944
p.I133M	HuO-3N1	bone	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.1944
p.I133M	NB(TU)1-10	autonomic_ganglia	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.1944
p.D117G	SIDM00183	Small Cell Lung Carcinoma	GDSC	DSGSET	DEG_SCF_TRCP1_1	0.1667
p.D117G	ACH-002154	Lung Cancer	CCLE	DSGSET	DEG_SCF_TRCP1_1	0.1667
p.D117G	LB647-SCLC	lung	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.1667
p.I126M	NB(TU)1-10	autonomic_ganglia	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.7618
p.I126M	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.7618
p.I126M	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.7618
p.I126M	CW-2	large_intestine	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.7618
p.I126M	HuO-3N1	bone	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.7618
p.Q128E	HT-1197	urinary_tract	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.6744
p.S137L	CPC-N	lung	COSMIC	DSGSET	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q49A88	Coiled-coil domain-containing protein 14	DEG_SCF_TRCP1_1	123:128	DSGSET	BTRC	0.97	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSET

Degron related mutations and impact score

Drug responses associated with CCDC14 mutations

All proteins holding degron of DSGSET