DegronMD - Q49MI3(CERKL)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S35Y	TCGA-55-1596	LUAD	TCGA	ERILLRGIF	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0833
p.S35Y	DO25481	LUAD	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0833
p.P36Q	TCGA-55-6979	LUAD	TCGA	ERILLRGIF	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1111
p.P36Q	TCGA-DA-A1IB	SKCM	TCGA	ERILLRGIF	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1111
p.P36Q	DO24110	LUAD	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1111
p.P36Q	DO38033	SKCM	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1111
p.E44K	TCGA-F4-6570	COAD	TCGA	ERILLRGIF	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.591
p.E44K	DO10443	COAD	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.591
p.V62A	DO233652	GACA	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.F52L	DO36115	PBCA	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.587
p.I46T	ACH-001664	Gastric Cancer	CCLE	ERILLRGIF	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.5966

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons