DegronMD

Uniprot ID: Q49MI3

Source protein: Ceramide kinase-like protein

Source gene: CERKL

Class: DEG_APCC_DBOX_1

Location: 44:52

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6153

ASA_SCORE: 51.8111

COIL: 0.197

CONS_SCORE: 0.2587

DSS_SCORE: 0.2184

HELIX: 0.0098

FCONS_SCORE: 0.9177

RIG_SCORE: 0.863

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S35Y	TCGA-55-1596	LUAD	TCGA	ERILLRGIF	DEG_APCC_DBOX_1	0.0833
p.S35Y	DO25481	LUAD	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	0.0833
p.P36Q	TCGA-55-6979	LUAD	TCGA	ERILLRGIF	DEG_APCC_DBOX_1	0.1111
p.P36Q	TCGA-DA-A1IB	SKCM	TCGA	ERILLRGIF	DEG_APCC_DBOX_1	0.1111
p.P36Q	DO24110	LUAD	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	0.1111
p.P36Q	DO38033	SKCM	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	0.1111
p.E44K	TCGA-F4-6570	COAD	TCGA	ERILLRGIF	DEG_APCC_DBOX_1	0.591
p.E44K	DO10443	COAD	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	0.591
p.V62A	DO233652	GACA	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	0.0556
p.F52L	DO36115	PBCA	ICGC	ERILLRGIF	DEG_APCC_DBOX_1	0.587
p.I46T	ACH-001664	Gastric Cancer	CCLE	ERILLRGIF	DEG_APCC_DBOX_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q49MI3	Ceramide kinase-like protein	DEG_APCC_DBOX_1	44:52	ERILLRGIF	APC,CDC20,FZR1	0.6153	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons