RIC1
UniProt ID: Q4ADV7
Entrez ID: 57589
Protein name: Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participat...
FUNCTION: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). {ECO:0000269|PubMed:16112082, ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:31932796}.
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GO - Biological processes (BP):
cranial skeletal system development [GO:1904888]; intracellular protein transport [GO:0006886]; negative regulation of cellular protein catabolic process [GO:1903363]; positive regulation of GTPase activity [GO:0043547]; regulation of extracellular matrix constituent secretion [GO:0003330]; retrogra...
cranial skeletal system development [GO:1904888]; intracellular protein transport [GO:0006886]; negative regulation of cellular protein catabolic process [GO:1903363]; positive regulation of GTPase activity [GO:0043547]; regulation of extracellular matrix constituent secretion [GO:0003330]; retrograde transport, endosome to Golgi [GO:0042147]
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GO - Molecular function (MF):
guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]...
guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]
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GO - Cellular component (CC):
cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066]; trans-Golgi network membrane [GO:0032588]...
cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066]; trans-Golgi network membrane [GO:0032588]
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RIC1
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Kaplan plot for RIC1 in
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*NOTE: the Kaplan plots were collected from OncoLnc