DegronMD

Uniprot ID: Q4ADV7

Source protein: Guanine nucleotide exchange factor subunit RIC1

Source gene: RIC1

Class: DEG_SCF_FBW7_1

Location: 1363:1370

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 103.2375

COIL: 0.9403

CONS_SCORE: 0.2466

DSS_SCORE: 0.7786

HELIX: 0.0323

FCONS_SCORE: 1.0357

RIG_SCORE: 0.6318

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1362N	SIDM00282	Colorectal Carcinoma	GDSC	MGKTPEQT	DEG_SCF_FBW7_1	0.3056
p.T1362N	CW-2	large_intestine	COSMIC	MGKTPEQT	DEG_SCF_FBW7_1	0.3056
p.Q1369P	SIDM00875	Breast Carcinoma	GDSC	MGKTPEQT	DEG_SCF_FBW7_1	0.5924
p.R1373W	SIDM01451	Pancreatic Carcinoma	GDSC	MGKTPEQT	DEG_SCF_FBW7_1	0.25
p.E1365G	MZ7-mel	skin	COSMIC	MGKTPEQT	DEG_SCF_FBW7_1	0.7199
p.V1354G	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	MGKTPEQT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4ADV7	Guanine nucleotide exchange factor subunit RIC1	DEG_SCF_FBW7_1	1363:1370	MGKTPEQT	FBXW7	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons