ERFE
UniProt ID: Q4G0M1
Entrez ID: 151176
Protein name: Erythroferrone (Complement C1q tumor necrosis factor-related protein 15) (Myonectin)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake ...
FUNCTION: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. {ECO:0000250|UniProtKB:Q6PGN1}.
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GO - Biological processes (BP):
cellular iron ion homeostasis [GO:0006879]; negative regulation of gluconeogenesis [GO:0045721]; positive regulation of fatty acid transport [GO:2000193]; positive regulation of glucose import [GO:0046326]; positive regulation of insulin receptor signaling pathway [GO:0046628]; regulation of fatty a...
cellular iron ion homeostasis [GO:0006879]; negative regulation of gluconeogenesis [GO:0045721]; positive regulation of fatty acid transport [GO:2000193]; positive regulation of glucose import [GO:0046326]; positive regulation of insulin receptor signaling pathway [GO:0046628]; regulation of fatty acid metabolic process [GO:0019217]
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GO - Molecular function (MF):
hormone activity [GO:0005179]; identical protein binding [GO:0042802]...
hormone activity [GO:0005179]; identical protein binding [GO:0042802]
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GO - Cellular component (CC):
extracellular region [GO:0005576]; extracellular space [GO:0005615]...
extracellular region [GO:0005576]; extracellular space [GO:0005615]
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ERFE
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*NOTE: the Kaplan plots were collected from OncoLnc