DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRDHLRLLI
Uniprot ID:
Q4G0M1
Source protein:
Erythroferrone
Source gene:
ERFE
Class:
DEG_APCC_DBOX_1
Location:
278:286
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7995
ASA_SCORE:
55.5222
COIL:
0.4169
CONS_SCORE:
0.5911
DSS_SCORE:
0.3732
HELIX:
0.0732
FCONS_SCORE:
1.0291
RIG_SCORE:
0.8205
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R279W
SIDM02039
Colorectal Carcinoma
GDSC
PRDHLRLLI
DEG_APCC_DBOX_1
0.8634
Drug responses associated with ERFE mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRDHLRLLI
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q4G0M1
Erythroferrone
DEG_APCC_DBOX_1
278:286
PRDHLRLLI
APC,CDC20,FZR1
0.7995
More...