DegronMD - Q4G0N4(NADK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R215M	TCGA-HE-7129	KIRP	TCGA	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation altering degron motif	0.7521
p.R215M	DO20786	KIRP	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation altering degron motif	0.7521
p.Y210C	TCGA-O8-A75V	LIHC	TCGA	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation rewiring degron network	0.2222
p.Y210C	DO49716	LIHC	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation rewiring degron network	0.2222
p.I222F	TCGA-RP-A694	SKCM	TCGA	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation altering degron motif	0.7415
p.I222F	DO51269	SKCM	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation altering degron motif	0.7415
p.F214L	DO228900	LICA	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation altering degron motif	0.6981
p.R211S	DO229041	LICA	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation rewiring degron network	0.25
p.R211C	DO229453	SKCA	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation rewiring degron network	0.25
p.R211C	SIDM01175	Other Sarcomas	GDSC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation rewiring degron network	0.25
p.R211C	SW684	soft tissue	COSMIC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation rewiring degron network	0.25
p.E210K	ACH-000757	Lung Cancer	CCLE	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation rewiring degron network	0.2222
p.E210K	A427	lung	COSMIC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation rewiring degron network	0.2222
p.R206H	HCT-15	large intestine	COSMIC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation rewiring degron network	0.1111
p.I229V	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation rewiring degron network	0.1389
p.V216A	CW-2	large intestine	COSMIC	FRWLWRQRI	DEG_MDM2_SWIB_1	214:222	Mutation altering degron motif	0.6936

Kaplan plot for NADK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NADK2

UniProt ID: Q4G0N4

Entrez ID: 133686

Protein name: NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NADK2 in