DegronMD

Uniprot ID: Q4G0N4

Source protein: NAD kinase 2, mitochondrial

Source gene: NADK2

Class: DEG_MDM2_SWIB_1

Location: 214:222

E3 ligase: MDM2

DEGRON score: 0.793

ASA_SCORE: 46.6

COIL: 0.2971

CONS_SCORE: 0.6005

DSS_SCORE: 0.019

HELIX: 0.018

FCONS_SCORE: 1.2945

RIG_SCORE: 0.9843

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R215M	TCGA-HE-7129	KIRP	TCGA	FRWLWRQRI	DEG_MDM2_SWIB_1	0.7521
p.R215M	DO20786	KIRP	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.7521
p.Y210C	TCGA-O8-A75V	LIHC	TCGA	FRWLWRQRI	DEG_MDM2_SWIB_1	0.2222
p.Y210C	DO49716	LIHC	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.2222
p.I222F	TCGA-RP-A694	SKCM	TCGA	FRWLWRQRI	DEG_MDM2_SWIB_1	0.7415
p.I222F	DO51269	SKCM	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.7415
p.F214L	DO228900	LICA	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.6981
p.R211S	DO229041	LICA	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.25
p.R211C	DO229453	SKCA	ICGC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.25
p.R211C	SIDM01175	Other Sarcomas	GDSC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.25
p.R211C	SW684	soft_tissue	COSMIC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.25
p.E210K	ACH-000757	Lung Cancer	CCLE	FRWLWRQRI	DEG_MDM2_SWIB_1	0.2222
p.E210K	A427	lung	COSMIC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.2222
p.R206H	HCT-15	large_intestine	COSMIC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.1111
p.I229V	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.1389
p.V216A	CW-2	large_intestine	COSMIC	FRWLWRQRI	DEG_MDM2_SWIB_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G0N4	NAD kinase 2, mitochondrial	DEG_MDM2_SWIB_1	214:222	FRWLWRQRI	MDM2	0.793	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons