FUNCTION: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Requir...
FUNCTION: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). {ECO:0000250}.
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GO - Biological processes (BP):
cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; spermatogenesis [GO:0007283]...
cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; spermatogenesis [GO:0007283]
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GO - Molecular function (MF):
ion channel activity [GO:0005216]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]...
ion channel activity [GO:0005216]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]
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GO - Cellular component (CC):
integral component of membrane [GO:0016021]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]...
integral component of membrane [GO:0016021]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]
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